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Items: 3

1.

Reciprocal gene editing defines targetable mutant H3.3 oncohistone effectors in pediatric glioma

(Submitter supplied) High-grade pediatric gliomas often contain histone H3.3 mutations, but open questions remain about oncogenic mechanisms. To address this gap, we performed ‘reciprocal gene editing’ using CRISPR-Cas9 to introduce H3.3 mutations (K27M, G34R) into H3.3-wildtype brain and glioma cells, while in parallel reverting pre-existing K27M mutations in glioma cells back to wildtype. Analyses of our reciprocally-edited cells indicate that H3.3 mutation leads to specific transcriptomic and epigenetic events, and associated cell biological changes including in xenograft assays. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24676
20 Samples
Download data: NARROWPEAK
Series
Accession:
GSE129765
ID:
200129765
2.

Illumina NovaSeq 6000 (Homo sapiens)

Platform
Accession:
GPL24676
ID:
100024676
3.

Line 17 WT H3K27me3 rep2

Organism:
Homo sapiens
Source name:
Line XVII DIPG
Platform:
GPL24676
Series:
GSE129765
Download data: NARROWPEAK
Sample
Accession:
GSM3721819
ID:
303721819
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db=gds|term=GSM3721819[Accession]|query=1|qty=2|blobid=MCID_66273aade53bb618e1cc8e10|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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