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Items: 3

1.

Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration

(Submitter supplied) Haematopoietic stem cells (HSCs) are normally quiescent, but have evolved mechanisms to respond to stress. Here, we evaluate haematopoietic regeneration induced by chemotherapy. We detect robust chromatin reorganization followed by increased transcription of transposable elements (TEs) during early recovery. TE transcripts bind to and activate the innate immune receptor melanoma differentiation-associated protein 5 (MDA5) that generates an inflammatory response that is necessary for HSCs to exit quiescence. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
24 Samples
Download data: CSV, TXT
Series
Accession:
GSE129631
ID:
200129631

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 3000 (Mus musculus)

Organism:
Mus musculus
1125 Series
42402 Samples
Download data
Platform
Accession:
GPL21493
ID:
100021493

3.

IFIH1WT_P1_2

Organism:
Mus musculus
Source name:
library of 96 IFIH1+/+ HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717644
ID:
303717644

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db=gds|term=GSM3717644[Accession]|query=1|qty=2|blobid=MCID_66e657fbf5aadd3332b9cc16|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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