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Items: 4

1.

AMPK links acetyl-coA homeostasis to BET recruitment in acute myeloid leukemia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL24247 GPL19057
30 Samples
Download data: BEDGRAPH
Series
Accession:
GSE128001
ID:
200128001
2.

AMPK links acetyl-coA homeostasis to BET recruitment in acute myeloid leukemia: ChIP-seq

(Submitter supplied) Altered metabolism fuels two hallmark properties of cancer cells, unlimited proliferation and differentiation blockade. AMP-activated protein kinase (AMPK) is a master regulator of bioenergetics crucial for glucose metabolism in acute myeloid leukemia (AML) and its inhibition delays leukemogenesis, but whether the metabolic function of AMPK alters AML epigenome remains unknown. Here, we demonstrate that AMPK maintains the epigenome of MLL-rearranged AML by linking acetyl-CoA homeostasis to BET bromodomain protein recruitment to chromatin. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24247
24 Samples
Download data: BEDGRAPH
Series
Accession:
GSE128000
ID:
200128000
3.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
4.

Input_KO_LGMP_1

Organism:
Mus musculus
Source name:
KO LGMP cells
Platform:
GPL24247
Series:
GSE128000 GSE128001
Download data: BEDGRAPH
Sample
Accession:
GSM3660027
ID:
303660027
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Supplemental Content

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