GSM3630268[Accession] - GEO DataSets

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Items: 4

Select item 2001272021.

Single-cell RNA sequencing-based CRISPRi screening resolves molecular drivers of early human endoderm development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platform:: GPL18573
42 Samples

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Accession:: GSE127202

ID:: 200127202

PubMed Full text in PMC Similar studies

Select item 2001272012.

Single-cell RNA sequencing-based CRISPRi screening resolves molecular drivers of early human endoderm development [set 2]

(Submitter supplied) Studies in vertebrates have outlined conserved molecular control of definitive endoderm (END) development. Yet, recent work also shows that key molecular aspects of human END regulation differ even from rodents. Differentiation of human pluripotent stem cells (hPSCs) to END offers a tractable system to study the molecular basis of normal and defective human-specific END development. Here, we interrogated dynamics in chromatin accessibility during differentiation of hPSCs to END, predicting DNA-binding proteins that may drive this cell fate transition. more...