GEO DataSets

(Submitter supplied) The majority of common variants associated with common diseases, as well as an unknown proportion of causal mutations for rare diseases, fall in noncoding regions of the genome. Although catalogs of noncoding regulatory elements are steadily improving, we have a limited understanding of the functional effects of mutations within them. Here, we performed saturation mutagenesis in conjunction with massively parallel reporter assays on 20 disease-associated gene promoters and enhancers, generating functional measurements for over 30,000 single nucleotide substitution and deletion mutations. more...

Organism:

Mus musculus; Homo sapiens

Type:

Other

Platforms:

GPL18573 GPL19057 GPL15520

198 Samples

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