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Items: 3

1.

CRISPR-based multimodal genetic screens in human iPSC-derived neurons

(Submitter supplied) CRISPR/Cas9-based functional genomics have transformed our ability to elucidate mammalian cell biology. Most previous CRISPR-based screens were implemented in cancer cell lines, rather than healthy, differentiated cells. Here, we describe a CRISPR interference (CRISPRi)-based platform for genetic screens in human neurons derived from induced pluripotent stem cells (iPSCs). We demonstrate robust and durable knockdown of endogenous genes in such neurons, and present results from three complementary genetic screens. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24676 GPL20301
14 Samples
Download data: MTX, TSV, TXT
Series
Accession:
GSE124703
ID:
200124703
2.

Illumina NovaSeq 6000 (Homo sapiens)

Platform
Accession:
GPL24676
ID:
100024676
3.

CROP-seq_iPSC_sgRNA_enrichment_for_lane1

Organism:
Homo sapiens
Source name:
Human iPSC
Platform:
GPL24676
Series:
GSE124703
Download data: TXT
Sample
Accession:
GSM3543620
ID:
303543620
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db=gds|term=GSM3543620[Accession]|query=1|qty=2|blobid=MCID_661da032d4af9b208931bb14|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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