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Items: 4

1.

TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24247 GPL21103
134 Samples
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Series
Accession:
GSE130627
ID:
200130627
2.

TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge [bulk RNA-seq]

(Submitter supplied) TREM2 is a microglial-specific gene implicated in late-onset Alzheimer's Disease (AD). Recent studies have identified that Trem2-deficient mice exhibit transcriptional changes in microglial gene expression that minimize the upregulation of lipid metabolism and lysosomal genes in AD disease models. We find that chronic phagocytic challenge from demyelination generates similiarly attenuated expression of lysosomal and lipid metabolism genes in microglia isolated from Trem2 knockout mouse brain.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
74 Samples
Download data: TAB
Series
Accession:
GSE124266
ID:
200124266
3.

Illumina HiSeq 4000 (Mus musculus)

Platform
Accession:
GPL21103
ID:
100021103
4.

Non-microglia cells from Trem2 -/- animal 1104 after 5 weeks on control diet

Organism:
Mus musculus
Source name:
Non-microglia isolated from whole brain
Platform:
GPL21103
Series:
GSE124266 GSE130627
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Sample
Accession:
GSM3526596
ID:
303526596
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Supplemental Content

db=gds|term=GSM3526596[Accession]|query=1|qty=2|blobid=MCID_6626e8744c13c13a0692782e|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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