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Items: 4

1.

STAT4 activation by leukemia inhibitory factor confers a therapeutic effect on intestinal inflammation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL11202 GPL17021
8 Samples
Download data: TXT
Series
Accession:
GSE124079
ID:
200124079
2.

STAT4 activation by leukemia inhibitory factor confers a therapeutic effect on intestinal inflammation [RNA-Seq]

(Submitter supplied) We report that microbiota dysregulation promotes LIF secretion by intestinal epithelial cells (IECs) in a mouse colitis model. LIF greatly activates STAT4 phosphorylation on multiple SPXX elements within the C-terminal transcription regulation domain. STAT4 and STAT3 act reciprocally on both canonical cis-inducible elements (SIEs) and noncanonical “AGG” elements at different loci. In lamina propria lymphocytes (LPLs), STAT4 activation by LIF blocks STAT3-dependent Il-17a/Il-17f promoter activation, whereas in IECs, LIF bypasses the extraordinarily low level of STAT4 to induce YAP gene expression via STAT3 activation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: XLSX
Series
Accession:
GSE124077
ID:
200124077
3.

Illumina HiSeq 2500 (Mus musculus)

Platform
Accession:
GPL17021
ID:
100017021
4.

IEC-S4-KO-control_1

Organism:
Mus musculus
Source name:
Intestinal epithelial cells
Platform:
GPL17021
Series:
GSE124077 GSE124079
Download data
Sample
Accession:
GSM3520237
ID:
303520237
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Supplemental Content

db=gds|term=GSM3520237[Accession]|query=1|qty=2|blobid=MCID_665566d56c05354989c7240c|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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