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Items: 3

1.

Multiple myeloma immunoglobulin lambda translocations portend poor prognosis

(Submitter supplied) Multiple myeloma is a malignancy of antibody-secreting plasma cells. Most patients benefit from current therapies, however, 20% of patients relapse or die within two years. To better understand and identify these ‘high-risk’ cases, we analyzed the translocation landscape of myeloma from 795 newly-diagnosed patients by whole genome sequencing from the CoMMpass study. Translocations involving the immunoglobulin lambda (IgL) locus were identified in 10% of patients, and were indicative of poor prognosis. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24676
28 Samples
Download data: BED, BW, TXT
Series
Accession:
GSE121912
ID:
200121912
2.

Illumina NovaSeq 6000 (Homo sapiens)

Platform
Accession:
GPL24676
ID:
100024676
3.

KMS12BM

Organism:
Homo sapiens
Source name:
Myeloma cell line
Platform:
GPL24676
Series:
GSE121912
Download data: BW
Sample
Accession:
GSM3449819
ID:
303449819
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