GSM3416296[Accession] - GEO DataSets

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Items: 4

Select item 2001208131.

HBO1 is required for the maintenance of leukaemia stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL17021 GPL19057
36 Samples

Download data: NARROWPEAK

Series

Accession:: GSE120813

ID:: 200120813

PubMed Similar studies

Select item 2001208112.

HBO1 is required for the maintenance of leukaemia stem cells [RNA-seq]

(Submitter supplied) Acute myeloid leukaemia (AML) is a heterogeneous disease characterised by transcriptional dysregulation resulting in a block in differentiation and increased malignant self-renewal. Various epigenetic therapies aimed at reversing these hallmarks of AML have progressed into clinical trials, with most showing modest efficacy due to an inability to effectively eradicate leukaemia stem cells (LSC). To specifically identify novel dependencies in LSC we screened a bespoke library of small hairpin RNAs (shRNAs) targeting chromatin regulators in a unique ex vivo model of LSC. more...