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Items: 3

1.

Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination

(Submitter supplied) The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is a classical nonhomologous end-joining (cNHEJ) factor. Loss of DNA-PKcs diminished mature B cell class switch recombination (CSR) to other isotypes, but not IgG1. Here, we show that expression of the kinase-dead DNA-PKcs (DNA-PKcsKD/KD) severely compromises CSR to IgG1. High-throughput sequencing analyses of CSR junctions reveal frequent accumulation of nonproductive interchromosomal translocations, inversions, and extensive end resection in DNA-PKcsKD/KD, but not DNA-PKcs-/- B cells. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL16417
16 Samples
Download data: XLSX
Series
Accession:
GSE117628
ID:
200117628
2.

Illumina MiSeq (Mus musculus)

Platform
Accession:
GPL16417
ID:
100016417
3.

DNA-PKcs-/- -1

Organism:
Mus musculus
Source name:
B cells
Platform:
GPL16417
Series:
GSE117628
Download data: XLSX
Sample
Accession:
GSM3305305
ID:
303305305
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