GSM3187888[Accession] - GEO DataSets

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Items: 4

Select item 2001157021.

Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL22245 GPL16791 GPL17021
48 Samples

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Accession:: GSE115702

ID:: 200115702

Select item 2001156992.

Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis [BrainMet_Othotopic]

(Submitter supplied) We find that malignant LUAD tumor cells grown in the brain microenvironment display significantly altered transcriptomic profiles when compared to tumor cells grown in monolayer or subcutaneously. Additionally, we characterize the reciprocal neuroinflammatory response of the surrounding brain stroma to metastatic LUAD. This dataset can be utilized to explore the mechanisms of LUAD cell plasticity as well as the co-adaptation of the brain microenvironment to metastatic disease.