GSM3187764[Accession] - GEO DataSets

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Items: 4

Select item 2001156931.

DNA accessibility is not the primary determinant of chromatin-mediated gene regulation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Saccharomyces cerevisiae

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL19057 GPL19756
98 Samples

Download data: BW

Series

Accession:: GSE115693

ID:: 200115693

Select item 2001156912.

DNA accessibility is not the primary determinant of chromatin-mediated gene regulation (mouse)

(Submitter supplied) DNA accessibility is thought to be of major importance in regulating gene expression. We test this hypothesis using a restriction enzyme as a probe of chromatin structure and as a proxy for transcription factors. We measured the digestion rate and the fraction of accessible DNA at all genomic AluI sites in budding yeast and mouse liver nuclei. Hepatocyte DNA is more accessible than yeast DNA, consistent with longer linkers between nucleosomes, and indicating that DNA accessibility is primarily determined by nucleosome spacing. more...