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Items: 4

1.

SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17021 GPL21273
91 Samples
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Series
Accession:
GSE112835
ID:
200112835
2.

SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [Bisulfite-seq]

(Submitter supplied) The oocyte epigenome plays critical roles in mammalian gametogenesis and embryogenesis. Yet, how it is established remains elusive. Here, we report that histone-lysine N-methyltransferase SETD2, an H3K36me3 methyltransferase, is a crucial regulator of the mouse oocyte epigenome. Deficiency in Setd2 leads to extensive alterations of the oocyte epigenome, including the loss of H3K36me3, failure in establishing the correct DNA methylome, invasion of H3K4me3 and H3K27me3 into former H3K36me3 territories and aberrant acquisition of H3K4me3 at imprinting control regions instead of DNA methylation. more...
Organism:
Mus musculus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL21273
11 Samples
Download data
Series
Accession:
GSE112833
ID:
200112833
3.

HiSeq X Ten (Mus musculus)

Platform
Accession:
GPL21273
ID:
100021273
4.

MethylC_FGO_Setd2_KO_5mC_rep1

Organism:
Mus musculus
Source name:
oocyte
Platform:
GPL21273
Series:
GSE112833 GSE112835
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Sample
Accession:
GSM3084614
ID:
303084614
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Supplemental Content

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