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Items: 4

1.

A genome-wide screen identifies E2F6 as critical factor for TMZ chemoresistance in EGFRvIII expressing GBM

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Other; Expression profiling by high throughput sequencing
Platforms:
GPL20301 GPL23227 GPL20795
46 Samples
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Series
Accession:
GSE112736
ID:
200112736
2.

A genome-wide screen identifies E2F6 as critical factor for TMZ chemoresistance in EGFRvIII expressing GBM (DNA-seq)

(Submitter supplied) We conducted a genome-wide screen by clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 library to identify genes which are particularly resistant to EGFRvIII GBM cells under the chemo-stress of TMZ. In vitro and in vivo validation of EGFRvIII-specific targets revealed several strong hits, including E2F6. Mechanistic studies demonstrated that E2F6 reveals its resistance to TMZ through NF-κB and TMZ inducement.
Organism:
Homo sapiens
Type:
Other
Platform:
GPL20795
10 Samples
Download data: XLSX
Series
Accession:
GSE112733
ID:
200112733
3.

HiSeq X Ten (Homo sapiens)

Platform
Accession:
GPL20795
ID:
100020795
4.

D7-NC-TMZ

Organism:
Homo sapiens
Source name:
U87 cell
Platform:
GPL20795
Series:
GSE112733 GSE112736
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Sample
Accession:
GSM3082704
ID:
303082704
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Supplemental Content

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