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Items: 4

1.

m7G methylation by METTL1 regulates let-7 microRNAs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing; Other; Expression profiling by array
Platforms:
GPL18460 GPL20844 GPL20301
34 Samples
Download data: TXT
Series
Accession:
GSE112182
ID:
200112182
2.

m7G methylation by METTL1 regulates let-7 microRNAs [BoRed-Seq & m7G-RIP-Seq A549]

(Submitter supplied) Methylation of N7-methylguanosine (m7G) is found at mRNA caps and at defined internal positions within abundant tRNAs and rRNAs. However, its detection within low abundance mRNAs and microRNAs (miRNAs) has been hampered by lack of sensitive detection strategies. Here, we adapt a chemical reactivity assay to detect internal m7G in RNA from eukaryotic cells. Using this approach, alongside a confirmational RNA immunoprecipitation assay, we identify m7G within miRNAs inhibiting cell migration, and show that METTL1 mediates this m7G methylation. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing; Other
Platforms:
GPL18460 GPL20301
14 Samples
Download data: TXT
Series
Accession:
GSE112181
ID:
200112181
3.

Illumina HiSeq 4000 (Homo sapiens)

Platform
Accession:
GPL20301
ID:
100020301
4.

A549 m7G-RIP Input Rep 5

Organism:
Homo sapiens
Source name:
A549 human lung adenocarcinoma cell line
Platform:
GPL20301
Series:
GSE112181 GSE112182
Download data
Sample
Accession:
GSM3059553
ID:
303059553
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