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Items: 4

1.

Small-molecule targeting of brachyury transcription factor addiction in chordoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11154 GPL18573
31 Samples
Download data: WIG
Series
Accession:
GSE109794
ID:
200109794
2.

Small-molecule targeting of brachyury transcription factor addiction in chordoma [ChIP-Seq]

(Submitter supplied) Chordoma is a primary bone cancer with no approved therapy. The identification of therapeutic targets in this disease has been challenging due to the infrequent occurrence of clinically actionable somatic mutations in chordoma tumors. Here we describe the discovery of therapeutically targetable chordoma dependencies via genome-scale CRISPR-Cas9 screening and focused small-molecule sensitivity profiling. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18573
28 Samples
Download data: WIG
Series
Accession:
GSE109791
ID:
200109791
3.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
4.

160831_NAT_input (MGH_4_NAT)

Organism:
Homo sapiens
Source name:
matched normal adjacent to MGH_4 chordoma
Platform:
GPL18573
Series:
GSE109791 GSE109794
Download data: WIG
Sample
Accession:
GSM2967372
ID:
302967372
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Supplemental Content

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