GSM2891655[Accession] - GEO DataSets

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Items: 4

Select item 2001085771.

Rescue of Fragile X syndrome by DNA methylation editing of the FMR1

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL16791
35 Samples

Download data: BW, COV, TXT, WIG

Series

Accession:: GSE108577

ID:: 200108577

PubMed Full text in PMC Similar studies

Select item 2001081712.

Rescue of Fragile X syndrome neurons by DNA methylation editing of the FMR1 gene [methylation]

(Submitter supplied) Fragile X syndrome (FXS), the most common genetic form of intellectual disability in male, is caused by silencing of the FMR1 gene by hypermethylation of the CGG expansion mutation in the 5’UTR region of FMR1 in FXS patients. Here, we applied recently developed DNA methylation editing tools to reverse this hypermethylation event. Targeted demethylation of the CGG expansion by dCas9-Tet1/sgRNA switched the heterochromatin status of the upstream FMR1 promoter to an active chromatin state restoring a persistent expression of FMR1 in FXS iPSCs. more...