GSM2857643[Accession] - GEO DataSets

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Items: 4

Select item 2001069231.

Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18460
20 Samples

Download data: BED, BIGWIG, TXT

Series

Accession:: GSE106923

ID:: 200106923

PubMed Full text in PMC Similar studies

Select item 2001069212.

Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer (ChIP-Seq)

(Submitter supplied) Metastasis is the cause of death for 90% of cancer patients, but little is known about how cancer cells adapt to and colonize new tissue environments. Using clinical samples and primary/metastatic cell lines, we found metastatic colorectal cancer (CRC) cells lose their colon-specific gene transcription program and gain a liver-specific gene transcription program as they metastasize in the liver. We revealed this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical and super-enhancers. more...