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Items: 4

1.

The H3.3 G34R glioma-associated mutation alters H3K9me3 and H3K36me3 chromatin modifications

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL18480 GPL21493
6 Samples
Download data: BW, TXT
Series
Accession:
GSE106205
ID:
200106205
2.

H3K9me3 and H3K36me3 ChIP-seq in WT and H3.3 G34R mouse ES cells

(Submitter supplied) Sequencing of paediatric gliomas has identified two common substitution mutations (K27M and G34R) in genes encoding histone H3.3. We introduced a single-copy H3.3 G34R targeted mutation in mouse ES cells and observed gains in H3K36me3 and H3K9me3 across the genome. Altered chromatin profiles correlated with enrichment of KDM4 A/B/C, a histone lysine (K9/K36) demethylase. RNA-seq of H3.3 G34R mutant showed disrupted gene expression patterns which also correlated with KDM4 enrichment. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18480
4 Samples
Download data: BW, TXT
Series
Accession:
GSE106203
ID:
200106203
3.

Illumina HiSeq 1500 (Mus musculus)

Platform
Accession:
GPL18480
ID:
100018480
4.

WT129_H3K9me3_ChIPSeq

Organism:
Mus musculus
Source name:
ES Cells
Platform:
GPL18480
Series:
GSE106203 GSE106205
Download data: BW
Sample
Accession:
GSM2831539
ID:
302831539
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Supplemental Content

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