GSM2757481[Accession] - GEO DataSets

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Items: 4

Select item 2001032141.

Early-life gene expression in neurons modulates lasting epigenetic states.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Lambdavirus lambda; Mus musculus

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

4 related Platforms
151 Samples

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Series

Accession:: GSE103214

ID:: 200103214

PubMed Full text in PMC Similar studies

Select item 2001032132.

Early-life gene expression in neurons modulates lasting epigenetic states. [Bisulfite-seq]

(Submitter supplied) In mammals during the early postnatal period the environment plays a critical role in promoting the final steps in neuronal development. While epigenetic factors are thought to contribute to this process, the underlying molecular mechanisms remain poorly understood. Here we show that in the brain during early life the DNA methyltransferase DNMT3A transiently binds across transcribed regions of lowly expressed genes, and its binding specifies the pattern of DNA methylation at CA sequences (mCA) within these genes. more...