GSM2691865[Accession] - GEO DataSets

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Items: 4

Select item 2001114631.

SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL18460 GPL16791
137 Samples

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Accession:: GSE111463

ID:: 200111463

PubMed Full text in PMC Similar studies

Select item 2001007082.

SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis [SLAM-seq]

(Submitter supplied) Defining direct targets of transcription factors and regulatory pathways is key to understanding their role in physiology and disease. Here we combine SLAM-seq, a novel method for direct quantification of newly synthesized mRNAs, with pharmacological and rapid chemical-genetic perturbation to interrogate primary transcriptional targets of BRD4 and MYC and define the response to BET bromodomain inhibitors (BETi). more...