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Items: 4

1.

Ultraconserved Enhancers Are Required for Normal Development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
4 related Platforms
26 Samples
Download data: FPKM_TRACKING
Series
Accession:
GSE100394
ID:
200100394
2.

Ultraconserved Enhancers Are Required for Normal Development [Drop-seq]

(Submitter supplied) Non-coding ultraconserved regions showing hundreds of consecutive bases of perfect evolutionary sequence conservation across mammalian genomes have intrigued biologists in the decade since they were first described. While many of these sequences are known to represent distant-acting enhancers, initial deletion studies in mice showed that their loss had no obvious impact on viability or fertility. To explore the discrepancy between extraordinary evolutionary constraint and an apparent lack of phenotypes when deleted in vivo, we used genome editing to create an expanded series of knockout mice lacking individual or combinations of ultraconserved brain enhancers near the essential neuronal transcription factor Arx. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL22245 GPL17021
6 Samples
Download data: TXT
Series
Accession:
GSE100384
ID:
200100384
3.

Illumina HiSeq 2500 (Homo sapiens; Mus musculus)

Organism:
Homo sapiens; Mus musculus
47 Series
2126 Samples
Download data
Platform
Accession:
GPL22245
ID:
100022245
4.

hs123-mCherry

Organism:
Mus musculus; Homo sapiens
Source name:
embryonic forebrain and 293T/17 cells
Platform:
GPL22245
Series:
GSE100384 GSE100394
Download data
Sample
Accession:
GSM2679967
ID:
302679967
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