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Items: 4

1.

Physiologic expression of Srsf2(P95H) causes myeloid expansion, impaired competitive stem cell function and initiates the myeloproliferative/myelodysplastic syndrome in vivo.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL21273 GPL19057
14 Samples
Download data: TXT, VCF
Series
Accession:
GSE99852
ID:
200099852
2.

Physiologic expression of Srsf2(P95H) causes myeloid expansion, impaired competitive stem cell function and initiates the myeloproliferative/myelodysplastic syndrome in vivo [WES]

(Submitter supplied) Mutations in the RNA splicing complex member SRSF2 are found frequently in myelodysplastic syndrome and related malignancies such as chronic myelomonocytic leukemia. These mutations cluster on proline 95, with P95H the most frequent. How SRSF2P95H mutations modify hematopoiesis and promote MDS/MPN development is not clear. We have established a conditionally activatable Srsf2P95H/+ knock-in allele which, when expressed within the hematopoietic stem cell populations caused profound myeloid bias, at the expense of erythroid and lymphoid cells, and a reduced frequency and competitive repopulation of HSCs. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL21273
6 Samples
Download data: TXT, VCF
Series
Accession:
GSE99850
ID:
200099850
3.

HiSeq X Ten (Mus musculus)

Platform
Accession:
GPL21273
ID:
100021273
4.

Whole Bone Marrow in vivo tamoxifen treated R26CreERT2 Srsf2 P95H from animal 108

Organism:
Mus musculus
Source name:
Whole Bone Marrow in vivo tamoxifen treated R26CreERT2 Srsf2 P95H
Platform:
GPL21273
Series:
GSE99850 GSE99852
Download data: TXT, VCF
Sample
Accession:
GSM2655966
ID:
302655966
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Supplemental Content

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