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Items: 4

1.

Western diet triggers NLRP3-dependent persistent functional reprogramming of myeloid cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL18480
48 Samples
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Series
Accession:
GSE97926
ID:
200097926
2.

Western diet triggers NLRP3-dependent persistent functional reprogramming of myeloid cells [RNA-Seq]

(Submitter supplied) Here we investigated whether sterile triggers of inflammation  induce trained immunity and thereby influence innate immune responses. Western diet (WD) feeding of Ldlr-/- mice induced systemic inflammation, which was undectable in serum soon after mice were shifted back to chow diet (CD). In contrast, myeloid cell responses towards innate stimuli remained broadly augmented. WD induced transcriptomic and epigenomic reprogramming of myeloid progenitor cells, leading to increased proliferation as well as enhanced innate immune and interferon responses towards in vivo LPS challenge. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18480
24 Samples
Download data: TXT
Series
Accession:
GSE97925
ID:
200097925
3.

Illumina HiSeq 1500 (Mus musculus)

Platform
Accession:
GPL18480
ID:
100018480
4.

Sample_1969

Organism:
Mus musculus
Source name:
WD>CD_PBS
Platform:
GPL18480
Series:
GSE97925 GSE97926
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Sample
Accession:
GSM2581136
ID:
302581136
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Supplemental Content

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