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Items: 4

1.

Application of the TGx-28.65 genomic biomarker to assess the genotoxicity of disperse orange and 1,2,4-benzenetriol in human cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL14550 GPL17077
26 Samples
Download data: TXT
Series
Accession:
GSE95192
ID:
200095192
2.

Application of the TGx-28.65 genomic biomarker to assess the genotoxicity of disperse orange and 1,2,4-benzenetriol in human cells [BT]

(Submitter supplied) In vitro gene expression signatures to predict toxicological responses can provide mechanistic context for human health risk assessment purposes. We previously developed the TGx-28.65 genomic biomarker from a database of gene expression profiles in human TK6 cells exposed to 28 well-known compounds, and it comprises 65 genes that can classify chemicals as DNA damaging or non-DNA damaging. In this study, we applied the TGx-28.65 genomic biomarker in parallel with the in vitro micronucleus (MN) assay to determine if two chemicals of regulatory interest at Health Canada, disperse orange (DO: the orange azo dye 3-[[4-[(4-Nitrophenyl)azo]phenyl]benzylamino]propanenitrile) and 1,2,4-benzenetriol (BT: a metabolite of benzene) are genotoxic or non-genotoxic. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
13 Samples
Download data: TXT, XLSX
Series
Accession:
GSE95188
ID:
200095188
3.

Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)

(Submitter supplied) SurePrint G3 Human GE v2 8x60K Microarray Design ID: 039494 Design Format: 8 x 60 K Control Grid: IS-62976-8-V2_60kby8_GX_EQC_201000210 Build Version: hg19:GRCh37:Feb2009 Arrays of this design have barcodes that begin with 16039494 or 2539494. Orientation: Features are numbered numbered Left-to-Right, Top-to-Bottom as scanned by an Agilent scanner (barcode on the left, DNA on the back surface, scanned through the glass), matching the FeatureNum output from Agilent's Feature Extraction software. more...
Organism:
Homo sapiens
574 Series
1 Related Platform
9521 Samples
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Platform
Accession:
GPL17077
ID:
100017077
4.

7hr BZ 20 µg/ml, 1

Organism:
Homo sapiens
Source name:
TK6 lymphoblastoid cell line (channel 1) TK6 lymphoblastoid cell line (channel 2)
Platform:
GPL17077
Series:
GSE95188 GSE95192
Download data: TXT
Sample
Accession:
GSM2498465
ID:
302498465
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