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Items: 4

1.

Application of the TGx-28.65 genomic biomarker to assess the genotoxicity of disperse orange and 1,2,4-benzenetriol in human cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL14550 GPL17077
26 Samples
Download data: TXT
Series
Accession:
GSE95192
ID:
200095192
2.

Application of the TGx-28.65 genomic biomarker to assess the genotoxicity of disperse orange and 1,2,4-benzenetriol in human cells [DO]

(Submitter supplied) In vitro gene expression signatures to predict toxicological responses can provide mechanistic context for human health risk assessment purposes. We previously developed the TGx-28.65 genomic biomarker from a database of gene expression profiles in human TK6 cells exposed to 28 well-known compounds, and it comprises 65 genes that can classify chemicals as DNA damaging or non-DNA damaging. In this study, we applied the TGx-28.65 genomic biomarker in parallel with the in vitro micronucleus (MN) assay to determine if two chemicals of regulatory interest at Health Canada, disperse orange (DO: the orange azo dye 3-[[4-[(4-Nitrophenyl)azo]phenyl]benzylamino]propanenitrile) and 1,2,4-benzenetriol (BT: a metabolite of benzene) are genotoxic or non-genotoxic. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL14550 GPL17077
13 Samples
Download data: TXT, XLSX
Series
Accession:
GSE95187
ID:
200095187
3.

Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Probe Name Version)

(Submitter supplied) SurePrint G3 Human GE 8x60K Microarray *** The ID column includes the Agilent Probe Names. A different version of this platform with the Agilent Feature Extraction feature numbers in the ID column is assigned accession number GPL13607. Protocol: see manufacturer's web site at http://www.agilent.com/
Organism:
Homo sapiens
381 Series
1 Related Platform
8105 Samples
Download data
Platform
Accession:
GPL14550
ID:
100014550
4.

7hr DO 750 µg/ml, 2

Organism:
Homo sapiens
Source name:
TK6 lymphoblastoid cell line (channel 1) TK6 lymphoblastoid cell line (channel 2)
Platform:
GPL14550
Series:
GSE95187 GSE95192
Download data: TXT
Sample
Accession:
GSM2498458
ID:
302498458
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