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Items: 3

1.

RNAseq data from Mesenchymal stem cells treated with TCDD or 1-methyl tryptophan

(Submitter supplied) Whole genome RNA-sequencing identified Nrf2, MAPK12 and IL-1a as important downstream targets of 1MT. We further demonstrate 1a1 and 1b1 activation by 1MT in IDO+ MSC following interferon-γ (IFNγ) activation, suggestive that 1MT-driven AHR signaling is uncoupled from IDO catalytic function. These observations support a novel paradigm by which AHR-activating compounds like 1MT can be used in cancer immunotherapy to stimulate a pro-inflammatory response, activating the body’s immune system to infiltrate and eradicate tumors.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21290
15 Samples
Download data: TXT
2.

Illumina HiSeq 3000 (Homo sapiens)

Platform
Accession:
GPL21290
ID:
100021290
3.

BMH6-TCDD

Organism:
Homo sapiens
Source name:
MSCs_TCDD (10nM)
Platform:
GPL21290
Series:
GSE95072
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Sample
Accession:
GSM2495740
ID:
302495740
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db=gds|term=GSM2495740[Accession]|query=1|qty=2|blobid=MCID_65d7981ebf197b1b5ec8c24a|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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