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Items: 4

1.

Super-enhancer-mediated RNA processing revealed by integrative microRNA network analysis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Super-enhancers are an emerging sub-class of regulatory regions controlling cell identity and disease genes. However, their biological function and impact on miRNA networks are unclear. Here we report that super-enhancers drive the biogenesis of master miRNAs crucial for cell identity by enhancing both transcription and Drosha/DGCR8-mediated primary miRNA processing. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other; Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL13112 GPL19057
15 Samples
Download data: BW
Series
Accession:
GSE89826
ID:
200089826
2.

Super-enhancer-mediated RNA processing revealed by integrative microRNA network analysis [ChrRNA-seq]

(Submitter supplied) Super-enhancers are an emerging sub-class of regulatory regions controlling cell identity and disease genes. However, their biological function and impact on miRNA networks are unclear. Here we report that super-enhancers drive the biogenesis of master miRNAs crucial for cell identity by enhancing both transcription and Drosha/DGCR8-mediated primary miRNA processing. Super-enhancers, together with broad H3K4me3 domains, shape a tissue-specific and evolutionarily conserved atlas of miRNA expression and function. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL19057
6 Samples
Download data: BW
Series
Accession:
GSE89821
ID:
200089821
3.

Illumina NextSeq 500 (Mus musculus)

Platform
Accession:
GPL19057
ID:
100019057
4.

ChrRNA-seq-WT-JQ1 - replicate 1

Organism:
Mus musculus
Source name:
V6.5 WT embryonic stem cells
Platform:
GPL19057
Series:
GSE89821 GSE89826
Download data: BW
Sample
Accession:
GSM2390057
ID:
302390057
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Supplemental Content

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