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Items: 3

1.

Efficient Mammary Gland Involution Requires c-Jun N-terminal kinase

(Submitter supplied) Involution returns the lactating mammary gland to a quiescent state after weaning. The mechanism of involution involves collapse of the mammary epithelial cell compartment. To test whether the cJUN NH2-terminal kinase (JNK) signal transduction pathway contributes to involution, we established mice with JNK deficiency in the mammary epithelium. We found that JNK is required for efficient involution. JNK deficiency did not alter the STAT3/5 or SMAD2/3 signaling pathways that have been previously implicated in this process. Nevertheless, JNK promotes the expression of genes that drive involution, including matrix metalloproteases, cathepsins, and BH3-only proteins. These data demonstrate that JNK has a key role in mammary gland involution post lactation.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
12 Samples
Download data: XLSX
Series
Accession:
GSE89495
ID:
200089495
2.

Illumina NextSeq 500 (Mus musculus)

Platform
Accession:
GPL19057
ID:
100019057
3.

WT_0D_3

Organism:
Mus musculus
Source name:
wild type_0 day_mammary gland
Platform:
GPL19057
Series:
GSE89495
Download data
Sample
Accession:
GSM2373898
ID:
302373898
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Supplemental Content

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