U.S. flag

An official website of the United States government

Format
Sort by

Send to:

Choose Destination

Search results

Items: 4

1.

Click chemistry enables comprehensive preclinical evaluation of targeted epigenetic therapies

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL18573 GPL11154
36 Samples
Download data: BED
Series
Accession:
GSE88751
ID:
200088751
2.

Click chemistry enables comprehensive preclinical evaluation of targeted epigenetic therapies [Click-Seq 2]

(Submitter supplied) The success of targeted therapies hinges on our ability to understand the molecular and cellular mechanism of action of these agents. Here we modify various BET bromodomain inhibitors, an exemplar novel targeted therapy, to create functionally conserved compounds that are amenable to click-chemistry and can be used as molecular probes in vitro and in vivo. Using click-proteomics and click-sequencing we provide new mechanistic insights to explain the gene regulatory function of BRD4 and the transcriptional changes invoked by BET inhibitors. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
10 Samples
Download data: BED
Series
Accession:
GSE88749
ID:
200088749
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

MV411_IBET-TCO+IBET

Organism:
Homo sapiens
Source name:
MV4;11 cell line
Platform:
GPL11154
Series:
GSE88749 GSE88751
Download data: BED
Sample
Accession:
GSM2345047
ID:
302345047
Format
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=GSM2345047[Accession]|query=1|qty=2|blobid=MCID_67b2594f5b08ab4a1749a957|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center