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Items: 4

1.

Click chemistry enables comprehensive preclinical evaluation of targeted epigenetic therapies

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL18573 GPL11154
36 Samples
Download data: BED
Series
Accession:
GSE88751
ID:
200088751
2.

Click chemistry enables comprehensive preclinical evaluation of targeted epigenetic therapies [ChIP-seq 1]

(Submitter supplied) The success of targeted therapies hinges on our ability to understand the molecular and cellular mechanism of action of these agents. Here we modify various BET bromodomain inhibitors, an exemplar novel targeted therapy, to create functionally conserved compounds that are amenable to click-chemistry and can be used as molecular probes in vitro and in vivo. Using click-proteomics and click-sequencing we provide new mechanistic insights to explain the gene regulatory function of BRD4 and the transcriptional changes invoked by BET inhibitors. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
3 Samples
Download data: BED
Series
Accession:
GSE88746
ID:
200088746
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

MV4;11_input DNA

Organism:
Homo sapiens
Source name:
MV4;11 cell line
Platform:
GPL11154
Series:
GSE88746 GSE88751
Download data
Sample
Accession:
GSM2345028
ID:
302345028
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Supplemental Content

db=gds|term=GSM2345028[Accession]|query=1|qty=2|blobid=MCID_669a02f856cb0a044e87f07a|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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