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Items: 3

1.

Direct and tissue-specific assessment of the damaging potential of regulatory SNPs

(Submitter supplied) In the era of GWAS and personalized medicine systematically deciphering the impact of non-coding sequence variation on the regulatory genome is a critical bottleneck. Here we present Sasquatch a novel computational approach to estimate and visualize the effects of noncoding-variants on transcription factor (TF) binding using DNase I footprint data. Developed to provide an unbiased approach to prioritise non-coding variants for functional analysis, Sasquatch performs exhaustive, k-mer based analysis of average footprints to determine any k-mers potential for TF binding and quantifies how this is changed by sequence variants. more...
Organism:
Homo sapiens; Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL18573 GPL19057 GPL15520
6 Samples
Download data: BEDGRAPH, WIG
Series
Accession:
GSE86393
ID:
200086393
2.

Illumina MiSeq (Homo sapiens)

Platform
Accession:
GPL15520
ID:
100015520
3.

Primary erythroid cells, biological replicate 1, growth protocol 1 (human)

Organism:
Homo sapiens
Source name:
Erythroid cells
Platform:
GPL15520
Series:
GSE86393
Download data: WIG
Sample
Accession:
GSM2301521
ID:
302301521
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