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Items: 3

1.

Physiologic expression of Sf3b1K700E causes impaired erythropoieses, aberrant splicing, and sensitivity to pharmacologic spliceosome modulation

(Submitter supplied) Over 80% of patients with the refractory anemia with ring sideroblasts subtype of myelodysplastic syndrome (MDS) have mutations in Splicing Factor 3B, Subunit 1 (SF3B1). We generated a conditional knock-in mouse model of the most common SF3B1 mutation, Sf3b1K700E. Sf3b1K700E mice develop macrocytic anemia due to a terminal erythroid maturation defect, erythroid dysplasia, and long-term hematopoietic stem cell (LT-HSC) expansion. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL11154 GPL19057
15 Samples
Download data: TXT
Series
Accession:
GSE85712
ID:
200085712

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 2000 (Homo sapiens)

Organism:
Homo sapiens
10523 Series
183350 Samples
Download data
Platform
Accession:
GPL11154
ID:
100011154

3.

MDS_253

Organism:
Homo sapiens
Source name:
Bone Marrow
Platform:
GPL11154
Series:
GSE85712
Download data: TXT
Sample
Accession:
GSM2282084
ID:
302282084

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db=gds|term=GSM2282084[Accession]|query=1|qty=3|blobid=MCID_67039293eda49c51f7a70570|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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