GSM2258988[Accession] - GEO DataSets

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Items: 4

Select item 2000851641.

DHX9 suppresses spurious RNA processing defects originating from the Alu invasion of the human genome

(Submitter supplied) Transposable elements are viewed as ‘selfish genetic elements’, yet they contribute to gene regulation and genome evolution in diverse ways. More than half of the human genome consists of transposable elements. With over 1 million insertions, Alu elements belong to the short interspersed nuclear element (SINE) family of repetitive elements, and with over 1 million insertions they make up more than 10% of the human genome. more...

Organism:: Homo sapiens; Drosophila melanogaster; Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

6 related Platforms
90 Samples

Download data: BED, BIGWIG

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Accession:: GSE85164

ID:: 200085164

Select item 2000851612.

DHX9 suppresses spurious RNA processing defects originating from the Alu invasion of the human genome [RNA-Seq]

(Submitter supplied) Transposable elements increase genetic diversity thus making them an important part of evolution and gene regulation in all organisms that carry these sequences. Bulk of our nascent transcriptome is comprised of transposable elements that have the propensity to form strong secondary structures. It is essential to resolve such strong secondary structures to maintain normal cellular function. Here, we show that the major nuclear RNA helicase DHX9/RHA interacts and remodels embedded Alu retrotransposable elements in the human transcriptome and B1 retrotransposable elements in the mouse transcriptome. more...