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Items: 3

1.

High Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML

(Submitter supplied) Bromodomain and extra-terminal domain (BET) family inhibitors offer a new approach to treating hematological malignancies. We used precision nuclear run-on transcription sequencing (PRO-seq) to create high-resolution maps of active RNA polymerases across the genome in t(8;21) acute myeloid leukemia (AML) that are exceptionally sensitive to BET inhibitors. PRO-seq identified over 1400 genes showing impaired release of promoter-proximal paused RNA polymerases, including the stem cell factor receptor tyrosine kinase KIT that is mutated in t(8;21) AML. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL11154 GPL18573
22 Samples
Download data: BEDGRAPH, TXT
Series
Accession:
GSE83660
ID:
200083660

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

2.

Illumina HiSeq 2000 (Homo sapiens)

Organism:
Homo sapiens
10622 Series
184694 Samples
Download data
Platform
Accession:
GPL11154
ID:
100011154

3.

AML-DMSO (PRO-seq)

Organism:
Homo sapiens
Source name:
primary acute myeloid leukemia patient cells
Platform:
GPL11154
Series:
GSE83660
Download data: BEDGRAPH
Sample
Accession:
GSM2212051
ID:
302212051

SRA Run Selector

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db=gds|term=GSM2212051[Accession]|query=1|qty=2|blobid=MCID_678ff84ff521160690630c14|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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