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Items: 3

1.

High Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML

(Submitter supplied) Bromodomain and extra-terminal domain (BET) family inhibitors offer a new approach to treating hematological malignancies. We used precision nuclear run-on transcription sequencing (PRO-seq) to create high-resolution maps of active RNA polymerases across the genome in t(8;21) acute myeloid leukemia (AML) that are exceptionally sensitive to BET inhibitors. PRO-seq identified over 1400 genes showing impaired release of promoter-proximal paused RNA polymerases, including the stem cell factor receptor tyrosine kinase KIT that is mutated in t(8;21) AML. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL11154 GPL18573
22 Samples
Download data: BEDGRAPH, TXT
2.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
3.

MS417-1hr (RNA-seq)

Organism:
Homo sapiens
Source name:
t(8;21)-containing acute myeloid leukemia cell line
Platform:
GPL11154
Series:
GSE83660
Download data: TXT
Sample
Accession:
GSM2212041
ID:
302212041
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db=gds|term=GSM2212041[Accession]|query=1|qty=2|blobid=MCID_66237bcc4c13c13a06495220|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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