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Items: 3

1.

Epigenetic targeting of immunocheckpoint PD-L1 by BET bromodomain inhibition

(Submitter supplied) Epigenetic regulators have emerged as exciting targets for cancer therapy. Additionally, restoration of antitumor immunity by blocking the PD-L1 signaling using antibodies has proven to be beneficial in cancer therapy. Here we show that BET bromodomain inhibition suppresses PD-L1 expression and restores antitumor immunity in ovarian cancer. CD274 (encoding PD-L1) is a direct target of BRD4-mediated gene transcription. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
4 Samples
Download data: TXT
Series
Accession:
GSE81698
ID:
200081698
2.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
3.

RNA-seq for BRD4 knockdown cells

Organism:
Homo sapiens
Source name:
PEO1 ovarian cancer cells
Platform:
GPL18573
Series:
GSE81698
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Sample
Accession:
GSM2171433
ID:
302171433
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db=gds|term=GSM2171433[Accession]|query=1|qty=2|blobid=MCID_6620853336ac342f8a837fa7|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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