GSM2170424[Accession] - GEO DataSets

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Items: 4

Select item 2000817741.

Differentiation and specification of resident tissue macrophages

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL18480
99 Samples

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Series

Accession:: GSE81774

ID:: 200081774

PubMed Full text in PMC Similar studies

Select item 2000816862.

Differentiation and specification of resident tissue macrophages [SMART-Seq2]

(Submitter supplied) Tissue resident macrophages are functionally diverse cells that share an embryonic mesodermal origin. However, the mechanism(s) that control their specification remain unclear. We performed transcriptional, molecular and in situ spatio-temporal analyses of macrophage development in mice. We report that Erythro-Myeloid Progenitors generate pre-macrophages (pMacs) that simultaneously colonize the head and caudal embryo from embryonic day (E)9.5 in a chemokine-receptor dependent manner, to further differentiate into tissue F4/80+ macrophages. more...