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Items: 4

1.

Epithelial-mesenchymal transition and acquired resistance to ALK inhibitors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platform:
GPL18573
26 Samples
Download data: BEDGRAPH, TXT, WIG
Series
Accession:
GSE81487
ID:
200081487
2.

Expression profiling by small RNA-seq for identifying miRNA associated with epithelial-mesenchymal transition and acquired resistance to ALK inhibitors

(Submitter supplied) Treatment with ALK tyrosine kinase inhibitors often elicits profound initial antitumor responses in ALK fusion-positive patients with lung adenocarcinoma. However, patients invariably develop acquired resistance to ALK inhibitors. In this study, we aimed to identify molecular events that limit the response to ALK inhibition using genetic and epigenetic approaches. To identify novel mechanisms of acquired resistance to ALK inhibitors, we established in vitro models of acquired resistance to ceritinib using H3122 cell. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL18573
6 Samples
Download data: TXT
Series
Accession:
GSE81486
ID:
200081486
3.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
4.

LR-NT-1_miRNA-seq

Organism:
Homo sapiens
Source name:
H3122 lung cancer cell line
Platform:
GPL18573
Series:
GSE81486 GSE81487
Download data: TXT
Sample
Accession:
GSM2154770
ID:
302154770
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Supplemental Content

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