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Items: 3

1.

Converting adult pancreatic α-cells into β-cells by targeting Dnmt1 and Arx

(Submitter supplied) After their destruction in adult mice, insulin-producing pancreatic beta-cells slowly regenerate from other islet cells, like glucagon-producing alpha-cells. However the molecular basis of this conversion is unknown. Moreover it remains unclear if this intra-islet cell conversion is relevant to human diseases with extensive beta-cell loss, like in type 1 diabetes (T1D). Here, we show that subsets of glucagon-expressing cells in subjects with T1D produce Insulin and other molecular features of beta-cells, accompanied by loss of the alpha-cell regulators DNA methyltransferase 1 (Dnmt1) and Aristaless-related homeobox (Arx). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
182 Samples
Download data: CSV
Series
Accession:
GSE79457
ID:
200079457
2.

Illumina NextSeq 500 (Mus musculus)

Platform
Accession:
GPL19057
ID:
100019057
3.

mouse_YFPpos_8w_cell11

Organism:
Mus musculus
Source name:
Single cell from pancreas, YFPpos_8w_cell11
Platform:
GPL19057
Series:
GSE79457
Download data: CSV
Sample
Accession:
GSM2096696
ID:
302096696
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Supplemental Content

db=gds|term=GSM2096696[Accession]|query=1|qty=2|blobid=MCID_661a38b76bc2bd5af4a49b44|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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