GSM207588[Accession] - GEO DataSets

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Items: 3

Select item 2000083881.

Epigenetic upregulation of B-cell inappropriate genes induces extinction of B-cell program in classical Hodgkin lymphoma

(Submitter supplied) A unique feature of the tumour cells (Hodgkin/Reed-Sternberg (HRS)) of classical Hodgkin lymphoma (cHL) is the loss of their B-cell phenotype despite their B-cell origin. Several lines of evidence suggest that epigenomic events, especially promoter DNA-methylation, are involved in this silencing of many B-cell associated genes. Here we show that DNA-demethylation alone or in conjunction with histone-acetylation is not able to reconstitute the B-cell gene expression program in cultured HRS cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
24 Samples

Download data: CEL, CHP, EXP

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Accession:: GSE8388

ID:: 200008388

Select item 1000000962.

[HG-U133A] Affymetrix Human Genome U133A Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The U133 set includes 2 arrays with a total of 44928 entries and was indexed 29-Jan-2002. more...