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Items: 3

1.

Not All H3K4 methylations are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification

(Submitter supplied) The spatiotemporal regulation of gene expression is central for cell-lineage specification during embryonic development and is achieved through the combinatorial action of transcription factors/co-factors and the epigenetic states at cis-regulatory elements. Previously, we reported that Mll2 (KMT2B)/COMPASS is responsible for the implementation of H3K4me3 at promoters of bivalent genes. Here, we show that Mll2/COMPASS can also implements H3K4me3 at some of the non-TSS regulatory elements, a subset of which share epigenetic signatures of active enhancers. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other
Platforms:
GPL17021 GPL19057
90 Samples
Download data: BW, TXT, XLS
Series
Accession:
GSE78708
ID:
200078708
2.

Illumina HiSeq 2500 (Mus musculus)

Platform
Accession:
GPL17021
ID:
100017021
3.

Mll2_Mll2KO_MLL2_deltaCXXC

Organism:
Mus musculus
Source name:
mouse embryonic stem cells
Platform:
GPL17021
Series:
GSE78708
Download data: BW
Sample
Accession:
GSM2073027
ID:
302073027
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