GSM2067930[Accession] - GEO DataSets

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Items: 4

Select item 2000781411.

MLL1 is essential for the senescence-associated secretory phenotype [ChIP-Seq]

(Submitter supplied) Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the senescence-associated secretory phenotype (SASP). Previous observations link the transcription-associated methyltransferase and oncoprotein MLL1 to the DDR, leading us to investigate the role of MLL1 in SASP expression. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL18573
16 Samples

Download data: BW

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Accession:: GSE78141

ID:: 200078141

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Select item 2000781422.

MLL1 is essential for the senescence-associated secretory phenotype

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the senescence-associated secretory phenotype (SASP). more...