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Items: 3

1.

p53 is a critical regulator of airway epithelial progenitor cell homeostasis.

(Submitter supplied) How progenitor cells regulate quiescence and differentiation is poorly understood. Here, we demonstrate that the tumor suppressor p53 regulates both proliferation and differentiation of club progenitor cells in the airway epithelium. We show that p53 loss decreases ciliated cell differentiation and increases the proliferative capacity of club progenitors, increasing epithelial cell density. p53 deficient progenitors generated a pseudostratified epithelium containing basal-like cells in vitro and contained an increased proportion of BASCs in vivo, suggesting that p53 suppresses multipotency during homeostasis. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
150 Samples
Download data: TXT
Series
Accession:
GSE78045
ID:
200078045
2.

Illumina NextSeq 500 (Mus musculus)

Platform
Accession:
GPL19057
ID:
100019057
3.

WT-D5-1-C68_S41

Organism:
Mus musculus
Source name:
lung_wild_type
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2065527
ID:
302065527
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db=gds|term=GSM2065527[Accession]|query=1|qty=2|blobid=MCID_669f6beb56cb0a044e10a174|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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