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Items: 4

1.

Activation of proto-oncogenes by disruption of chromosome neighborhoods [5C-Seq]

(Submitter supplied) Mutations such as gene fusion, translocation and focal amplification are a frequent cause of proto-oncogene activation during tumorigenesis, but such mutations do not explain all cases of proto-oncogene activation. Here we show that disruption of local chromosome conformation can also activate proto-oncogenes in human cells. We mapped chromosome structures in T-cell acute lymphoblastic leukemia (T-ALL), and found that active oncogenes and silent proto-oncogenes generally occur within insulated neighborhoods formed by the looping of two interacting CTCF sites co-occupied by cohesin. more...
Organism:
Homo sapiens
Type:
Other
Platforms:
GPL11154 GPL15520
9 Samples
Download data: MATRIX
Series
Accession:
GSE77142
ID:
200077142
2.

Activation of proto-oncogenes by disruption of chromosome neighborhoods

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL11154 GPL15520 GPL16791
22 Samples
Download data: BED12, WIG
Series
Accession:
GSE68978
ID:
200068978
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

Lmo2Del_rep2_hiseq

Organism:
Homo sapiens
Source name:
Lmo2Del
Platform:
GPL11154
Series:
GSE68978 GSE77142
Download data
Sample
Accession:
GSM2044775
ID:
302044775
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Supplemental Content

db=gds|term=GSM2044775[Accession]|query=1|qty=2|blobid=MCID_66296f8cf4364867153d2b8e|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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