GSM2026243[Accession] - GEO DataSets

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Items: 4

Select item 2000764811.

Cell-of-origin specific 3D genome structure acquired during somatic cell reprogramming

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by array

Platforms:: GPL10787 GPL17021 GPL19057
85 Samples

Download data: NARROWPEAK, TXT

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Accession:: GSE76481

ID:: 200076481

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000764782.

Cell-of-origin specific 3D genome structure acquired during somatic cell reprogramming [ChIP-Seq]

(Submitter supplied) We studied genome topology dynamics during reprogramming of different somatic cell types with highly distinct genome conformations. We find large-scale TAD repositioning and alterations of tissue-restricted genomic neighborhoods and chromatin loops, effectively erasing the somatic cell specific genome structures while establishing an embryonic stem cell-like 3D genome. Yet, early passage iPSCs carry topological hallmarks that enable discerning their cell-of-origin. more...