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Items: 3

1.

Direct identification of hundreds of expression-modulating variants using a multiplexed reporter assay

(Submitter supplied) Although genetic studies have identified many hundreds of loci associated with human traits and diseases, pinpointing the causal alleles remains difficult, particularly for non-coding variants. To address this challenge, we have enhanced the sensitivity and reproducibility of the massively parallel reporter assay (MPRA), adapting it to identify variants that directly modulate gene expression. We then applied it to over 29,000 single nucleotide and insertion/deletion polymorphisms from 3,965 cis-expression quantitative trait loci (eQTL). more...
Organism:
Homo sapiens; synthetic construct
Type:
Other
Platforms:
GPL16791 GPL19604
31 Samples
Download data: TAB, TXT
Series
Accession:
GSE75661
ID:
200075661
2.

Illumina HiSeq 2500 (synthetic construct)

Organism:
synthetic construct
54 Series
5348 Samples
Download data
Platform
Accession:
GPL19604
ID:
100019604
3.

Plasmid_replicate_5_79k_Pool

Organism:
synthetic construct
Source name:
plasmid DNA
Platform:
GPL19604
Series:
GSE75661
Download data
Sample
Accession:
GSM1962999
ID:
301962999
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Supplemental Content

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