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Items: 3

1.

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution

(Submitter supplied) In this study, using a murine model of Ph+ acute lymphoblastic leukemia (Ph+ ALL), a combined pharmacological profile and drug selection experimental approach identified distinct stages of tumor clonal evolution with vulnerabilities to sets of small molecules. Through genotypic, phenotypic, signaling, and binding measurements, we identified the mutation V299L in the ABL1 kinase domain as mediator for an on-target ABL1 inhibition and hence the sensitization phenotype. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
10 Samples
Download data: CSV
Series
Accession:
GSE72910
ID:
200072910

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina NextSeq 500 (Mus musculus)

Organism:
Mus musculus
10368 Series
297601 Samples
Download data
Platform
Accession:
GPL19057
ID:
100019057

3.

ALL (DMSO 1x)

Organism:
Mus musculus
Source name:
Ph+ ALL cells
Platform:
GPL19057
Series:
GSE72910
Download data
Sample
Accession:
GSM1874423
ID:
301874423

SRA Run Selector

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db=gds|term=GSM1874423[Accession]|query=1|qty=2|blobid=MCID_67596e6fc087e36732a4a98e|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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