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Items: 3

1.

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(Submitter supplied) Nrf2 (NF-E2-related factor-2) transcription factor regulates oxidative/xenobiotic stress response and also represses inflammation. However, the mechanisms how Nrf2 alleviates inflammation are still unclear. Here, we demonstrate that Nrf2 interferes with lipopolysaccharide-induced transcriptional upregulation of proinflammatory cytokines, including IL-6 and IL-1β. ChIP-seq and ChIP-qPCR analyses revealed that Nrf2 binds to the proximity of these genes in macrophages and inhibits RNA Pol II recruitment. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
12 Samples
Download data: TXT
Series
Accession:
GSE71263
ID:
200071263
2.

Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)

(Submitter supplied) Designed to truly represent all known genes in the mouse genome and their resulting transcripts, Agilent's Whole Mouse Genome Oligo – 4X44K microarray is comprised of 41,534 60-mer oligonucleotide probes representing over 41,000 mouse genes and transcripts. Content for this microarray was generated from leading public databases, including RefSeq, RIKEN, NIA, Ensembl, RIKEN, UCSC Goldenpath, and Unigene. more...
Organism:
Mus musculus
16 DataSets
653 Series
1 Related Platform
10672 Samples
Download data
Platform
Accession:
GPL7202
ID:
100007202
3.

M1-BMDMs_Keap1CKO_replicate2

Organism:
Mus musculus
Source name:
BMDMs, Keap1CKO, LPS and IFNg, 6hrs, replicate2
Platform:
GPL7202
Series:
GSE71263
Download data: TXT
Sample
Accession:
GSM1831612
ID:
301831612
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